![]() If it’s too much, feel free to skip to the next section. While this may be a little sciency for some, it’s pretty cool. Exactly how these medications go about “lowering” estrogen levels is the primary driver of their differences. How Clomid and Letrozole WorkĪs mentioned, Clomid and Letrozole both exert their primary effect by “reducing” estrogen levels. In short, both medications help to improve fertility in two main ways, (1) increasing the number of mature high-quality eggs that are developed each cycle and (2) inducing ovulation. These hormones, particularly FSH, stimulate the development and release of the egg. The Hypothalamus in the brain interprets these low estrogen levels as a need to make FSH and LH. Both medications achieve this by “lowering” estrogen levels in the body. What are Clomid (Clomiphene Citrate) and Letrozole (Femara)Ĭlomid and Letrozole are oral medications that help the ovaries to develop and ovulate high-quality eggs.
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